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Pemigatinib Chemical Structure

Pemigatinib

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP31812CAS No. ：1513857-77-6Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 1513857-77-6 Cat. No. BCP31812
Name Pemigatinib
Synonyms INCB054828; INCB-054828; INCB 054828; INCB54828; INCB 54828; INCB-54828;
SMILES CCN1C2=C3C=C(NC3=NC=C2CN(C1=O)C4=C(C(=CC(=C4F)OC)OC)F)CN5CCOCC5
Chemical Name
Formula C24H27F2N5O4 M. Wt 487.5
Purity 98% Storage Store at 4-8°C
Description Pemigatinib is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) types 1, 2, and 3 (FGFR1/2/3), with potential antineoplastic activity. Pemigatinib binds to and inhibits FGFR1/2/3, which may result in the inhibition of FGFR1/2/3-related signal transduction pathways. This inhibits proliferation in FGFR1/2/3-overexpressing tumor cells. FGFR, a family of receptor tyrosine kinases upregulated in many tumor cell types, plays a key role in cellular proliferation, migration, and survival.
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