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CAS No. | 1265966-31-1 | Cat. No. | BCP29576 |
Name | S49076 HCl | ||
Synonyms | 1265965-19-2;S 49076 HCl;S-49076 HCl;S-49076 Hydrochloride;S49076 Hydrochloride;S 49076 Hydrochloride; | ||
SMILES | C1COCCN1CC2=CNC(=C2)C=C3C4=C(C=CC(=C4)CN5C(=O)CSC5=O)NC3=O.Cl | ||
Chemical Name | |||
Formula | C22H23ClN4O4S | M. Wt | 474.96 |
Purity | 98% | Storage | Store at 4-8°C |
Description | S49076 is an effective inhibitor of MET, AXL/MER, and FGFR1/2/3. S49076 potently blocked cellular phosphorylation of MET, AXL, and FGFRs and inhibited downstream signaling in vitro and in vivo. In cell models, S49076 inhibited the proliferation of MET- and FGFR2-dependent gastric cancer cells blocked MET-driven migration of lung carcinoma cells, and inhibited colony formation of hepatocarcinoma cells expressing FGFR1/2 and AXL. In tumor xenograft models, a good pharmacokinetic/pharmacodynamic relationship for MET and FGFR2 inhibition following oral administration of S49076 was established and correlated well with impact on tumor growth. |
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