BO-264 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 2408648-20-2 | Cat. No. | BCP33848 |
| Name | BO-264 | ||
| Synonyms | BO 264; BO264; | ||
| SMILES | COC1=CC=C(C=C1)C2=NOC(=C2)NC3=NC(=NC=C3)N4CCOCC4 | ||
| Chemical Name | |||
| Formula | C18H19N5O3 | M. Wt | 353.38 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | BO-264 is a highly potent and orally active transforming acidic coiled-coil 3 (TACC3) inhibitor with an IC50 of 188 nM and a Kd of 1.5 nM. BO-264 demonstrated superior anti-proliferative activity to the two currently reported TACC3 inhibitors, especially in aggressive breast cancer subtypes, basal and HER2+, via spindle assembly checkpoint (SAC)-dependent mitotic arrest, DNA damage and apoptosis, while the cytotoxicity against normal breast cells was negligible. | ||
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