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CAS No. | 1708971-55-4 | Cat. No. | BCP25143 |
Name | FGF401 | ||
Synonyms | FGF-401; FGF 401; Roblitinib; | ||
SMILES | CN1CCN(C(=O)C1)CC2=C(N=C3C(=C2)CCCN3C(=O)NC4=NC=C(C(=C4)NCCOC)C#N)C=O | ||
Chemical Name | |||
Formula | C25H30N8O4 | M. Wt | 506.56 |
Purity | 98% | Storage | Store at 4-8°C |
Description | FGF401 is an inhibitor of human fibroblast growth factor receptor 4 (FGFR4), with potential antineoplastic activity. Upon administration, FGF401 binds to and inhibits the activity of FGFR4, which leads to an inhibition of tumor cell proliferation in FGFR4-overexpressing cells. FGFR4 is a receptor tyrosine kinase upregulated in certain tumor cells and involved in tumor cell proliferation, differentiation, angiogenesis, and survival. |
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