AZD-8529 mesylate New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1314217-69-0 | Cat. No. | BCP37624 |
| Name | AZD-8529 mesylate | ||
| Synonyms | AZD8529 mesylate；AZD 8529 mesylate; | ||
| SMILES | CC1=CC(=CC2=C1C(=O)N(C2)CC3=CC=C(C=C3)OC(F)(F)F)C4=NC(=NO4)CN5CCNCC5.CS(=O)(=O)O | ||
| Chemical Name | |||
| Formula | C25H28F3N5O6S | M. Wt | 583.58 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | AZD-8529 is a a positive allosteric modulator at the mGluR2 receptor. AZD8529 decreases Nicotine Self-Administration and Relapse in Squirrel Monkeys. AZD8529 potentiated agonist-induced activation of mGluR2 in the membrane-binding assay and in primate cortex, hippocampus, and striatum. In monkeys, AZD8529 decreased nicotine self-administration at doses (.3-3 mg/kg) that did not affect food self-administration. AZD8529 also reduced nicotine priming- and cue-induced reinstatement of nicotine seeking after extinction of the drug-reinforced responding. In rats, AZD8529 decreased nicotine-induced accumbens dopamine release. The positive allosteric modulators of metabotropic glutamate receptor 2 should be considered for relapse prevention. | ||
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