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MG-132 Chemical Structure

MG-132

Data Sheet For research use only. Not for human use.
Cat. No. :BCP02537CAS No. :133407-82-6Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 133407-82-6 Cat. No. BCP02537
Related Products 1211877-36-9((R)-MG-132)
Name MG-132
Synonyms MG132;MG 132;
SMILES O=C(OCC1=CC=CC=C1)N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C=O)=O)=O
Chemical Name
Formula C26H41N3O5 M. Wt 475.62
Purity 98% Storage Store at 4-8°C
Description MG132 is a specific, potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM) . It reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable strains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. MG132 activates c-Jun N-terminal kinase (JNK1), which initiates apoptosis. MG132 also inhibits NF-κB activation with an IC50 of 3 µM and prevents β-secretase cleavage. MG-132 induces MCPIP1 expression; induces C6 glioma cell apoptosis via oxidative stress; induces AIF nuclear translocation through down-regulation of ERK and Akt/mTOR pathway.
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