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CAS No. | 133407-82-6 | Cat. No. | BCP02537 |
Related Products | 1211877-36-9((R)-MG-132) | ||
Name | MG-132 | ||
Synonyms | MG132;MG 132; | ||
SMILES | O=C(OCC1=CC=CC=C1)N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C=O)=O)=O | ||
Chemical Name | |||
Formula | C26H41N3O5 | M. Wt | 475.62 |
Purity | 98% | Storage | Store at 4-8°C |
Description | MG132 is a specific, potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM) . It reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable strains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. MG132 activates c-Jun N-terminal kinase (JNK1), which initiates apoptosis. MG132 also inhibits NF-κB activation with an IC50 of 3 µM and prevents β-secretase cleavage. MG-132 induces MCPIP1 expression; induces C6 glioma cell apoptosis via oxidative stress; induces AIF nuclear translocation through down-regulation of ERK and Akt/mTOR pathway. |
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