BMS-986142
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1643368-58-4 | Cat. No. | BCP29622 |
| Name | BMS-986142 | ||
| Synonyms | BMS 986142; BMS986142; | ||
| SMILES | O=C(C1=CC(F)=[C@]([C@]2=CC=CC(N3C(N(C)C4=C(C=CC=C4F)C3=O)=O)=C2C)C5=C1NC6=C5CC[C@H](C(C)(O)C)C6)N | ||
| Chemical Name | |||
| Formula | C32H30F2N4O4 | M. Wt | 572.61 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | BMS-986142 is a potent, selective, reversible BTK inhibitor. BMS-986142 shows BTK IC50 = 0.5nM; human WB IC50 = 90 nM. In molecule of BMS-986142, two atropisomeric centers were rotationally locked to provide a single, stable atropisomer, resulting in enhanced potency and selectivity as well as a reduction in safety liabilities. With significantly enhanced potency and selectivity, excellent in vivo properties and efficacy, and a very desirable tolerability and safety profile, BMS-986142 was advanced into clinical studies. | ||
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