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BMS-986195 Chemical Structure

BMS-986195

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP29496CAS No. ：1912445-55-6Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 1912445-55-6 Cat. No. BCP29496
Name BMS-986195
Synonyms BMS986195; BMS986195;
SMILES FC1=C(N2CCC[C@H](NC(C#CC)=O)C2)C3=C(NC(C)=C3C)C(C(N)=O)=C1
Chemical Name
Formula C20H23FN4O2 M. Wt 370.43
Purity 98% Storage Store at 4-8°C
Description BMS-986195 is a potent, covalent, irreversible inhibitor of Bruton’s tyrosine kinase (BTK), a member of the Tec family of non-receptor tyrosine kinases essential in antigen-dependent B-cell signaling and function. BMS-986195 is more than 5000-fold selective for BTK over all kinases outside of the Tec family, and selectivity ranges from 9- to 1010-fold within the Tec family. BMS-986195 inactivated BTK in human whole blood with a rapid rate of inactivation (3.5×10-4 nM-1·min-1) and potently inhibited antigen-dependent interleukin-6 production, CD86 expression and proliferation in B cells (IC50 <1 nM) without effect on antigen-independent measures in the same cells.
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