FTI-276 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 170006-72-1 | Cat. No. | BCP37170 |
| Name | FTI-276 | ||
| Synonyms | FTI276; FTI 276; | ||
| SMILES | CSCCC(C(=O)O)NC(=O)C1=C(C=C(C=C1)NCC(CS)N)C2=CC=CC=C2 | ||
| Chemical Name | |||
| Formula | C21H27N3O3S2 | M. Wt | 433.59 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | FTI-276 is a potent and selective farnesyltransferase inhibitor, which is also a tetrapeptide mimetic of the carboxyl terminus of K-Ras4B. FTI-276 blocked the growth in nude mice of a human lung carcinoma that expresses the two most prevalent genetic alterations in human cancers (K-Ras oncogenic mutation and deletion in the tumor suppressor gene p53). In contrast, FTI-276 did not inhibit tumor growth of a human lung carcinoma that harbors no Ras mutations. Furthermore, FTI-276 inhibited oncogenic signaling and tumor growth of NIH 3T3 cells transformed with the ras but not the raf oncogene. | ||
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