BMS-214662 hydrochloride New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 195981-08-9 | Cat. No. | BCP19824 |
| Name | BMS-214662 hydrochloride | ||
| Synonyms | BMS-214662 HC;ARQ171; ARQ 171; ARQ-171; BMS214662; BMS214662; BMS-214662; | ||
| SMILES | C1C(N(CC2=C(N1CC3=CN=CN3)C=CC(=C2)C#N)S(=O)(=O)C4=CC=CS4)CC5=CC=CC=C5.Cl | ||
| Chemical Name | |||
| Formula | C25H24ClN5O2S2 | M. Wt | 526.07 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | BMS-214662 is a Farnesyltransferase inhibitor , is also a nonsedating benzodiazepine derivative with potential antineoplastic activity. BMS-214662 inhibits the enzyme farnesyltransferase and the post-translational farnesylation of number of proteins involved in signal transduction, which may result in the inhibition of Ras function and apoptosis in susceptible tumor cells. This agent may reverse the malignant phenotype of H-Ras-transformed cells and has been shown to be active against tumor cells with and without Ras mutations. | ||
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