FTI-2148 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 251577-09-0 | Cat. No. | BCP37168 |
| Name | FTI-2148 | ||
| Synonyms | FTI 2148; FTI2148;Hamilton/Sebti Compound 10a; | ||
| SMILES | CC1=CC=CC=C1C2=C(C=CC(=C2)CNCC3=CN=CN3)C(=O)NC(CCSC)C(=O)O | ||
| Chemical Name | |||
| Formula | C24H28N4O3S | M. Wt | 452.57 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | FTI-2148 is a potent farnesyltransferase inhibitor with potential antitumor activity. FTI-2148 is highly selective for FTase (IC50, 1.4 nM) over GGTase I (IC50, 1700 nM). FTI-2148 suppressed the growth of the human lung adenocarcinoma A-549 cells in nude mice by 33, 67, and 91% in a dose-dependent manner. Combination therapy of FTI-2148 with either cisplatin, gemcitabine, or Taxol resulted in a greater antitumor efficacy than monotherapy. | ||
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