ABT-100 New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP42635CAS No. ：450839-40-4Purity：98%

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CAS No.	450839-40-4	Cat. No.	BCP42635
Name	ABT-100
Synonyms	ABT 100; ABT100; A367074; A 367074; A-367074;
SMILES	CN1C=NC=C1C(COC2=C(C=C(C=C2)C#N)C3=CC=C(C=C3)OC(F)(F)F)(C4=CC=C(C=C4)C#N)O
Chemical Name
Formula	C27H19F3N4O3	M. Wt	504.46
Purity	98%	Storage	Store at 4-8°C
Description	ABT-100 is an orally bioavailable farnesyltransferase inhibitor. ABT-100 inhibited proliferation of cells in vitro carrying oncogenic H-Ras (EJ-1 bladder; IC(50) 2.2 nmol/L), Ki-Ras (DLD-1 colon, MDA-MB-231 breast, HCT-116 colon, and MiaPaCa-2 pancreatic; IC(50) range, 3.8-9.2 nmol/L), and wild-type Ras (PC-3 and DU-145; IC(50), 70 and 818 nmol/L, respectively) as well as clonogenic potential. ABT-100 shows 70% to 80% oral bioavailability in mice. ABT-100 regressed EJ-1 tumors (2-12.5 mg/kg/d s.c., every day for 21 days) and showed significant efficacy in DLD-1, LX-1, MiaPaCa-2, or PC-3 tumor-bearing mice (6.25-50 mg/kg/d s.c. once daily or twice daily orally).