Erlotinib

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP09267CAS No. ：183321-74-6Purity：99%

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CAS No.	183321-74-6	Cat. No.	BCP09267
Related Products	183319-69-9（Erlotinib HCl）
Name	Erlotinib
Synonyms	NSC 718781; R1415;R 1415;R-1415CP-358,774; CP-358774; CP358774; OSI-774; OSI 774; OSI774; Erlotinib free base;
SMILES
Chemical Name
Formula	C22H23N3O4	M. Wt	393.44
Purity	99%	Storage	Store at 4-8°C
Description	Erlotinib is an epidermal growth factor receptor inhibitor (EGFR inhibitor). Erlotinib HCl was approved. Erlotinib binds in a reversible fashion to the adenosine triphosphate (ATP) binding site of the receptor. For the signal to be transmitted, two EGFR molecules need to come together to form a homodimer. These then use the molecule of ATP to trans-phosphorylate each other on tyrosine residues, which generates phosphotyrosine residues, recruiting the phosphotyrosine-binding proteins to EGFR to assemble protein complexes that transduce signal cascades to the nucleus or activate other cellular biochemical processes. When erlotinib binds to EGFR, formation of phosphotyrosine residues in EGFR is not possible and the signal cascades are not initiated.