APS-2-79 New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP24938CAS No. ：2002381-25-9Purity：98%

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CAS No.	2002381-25-9	Cat. No.	BCP24938
Name	APS-2-79
Synonyms	APS 2-79; APS2-79; APS-279; APS 279; APS279;
SMILES	CC1=C(C=CC(=C1)OC2=CC=CC=C2)NC3=NC=NC4=CC(=C(C=C43)OC)OC
Chemical Name
Formula	C23H21N3O3	M. Wt	387.43
Purity	98%	Storage	Store at 4-8°C
Description	APS-2-79 is a KSR-dependent MAPK modulator. APS-2-79 modulates KSR-dependent MAPK signalling by antagonizing RAF heterodimerization as well as the conformational changes required for phosphorylation and activation of KSR-bound MEK (mitogen-activated protein kinase kinase). APS-2-79 increased the potency of several MEK inhibitors specifically within Ras-mutant cell lines by antagonizing release of negative feedback signalling, demonstrating the potential of targeting KSR to improve the efficacy of current MAPK inhibitors. Co-targeting of enzymatic and scaffolding activities within Ras-MAPK signalling complexes is a therapeutic strategy for overcoming Ras-driven cancers.