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ASN007 Chemical Structure

ASN007

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP48479CAS No. ：2055597-12-9Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 2055597-12-9 Cat. No. BCP48479
Related Products 2055597-39-0（ASN007 benzenesulfonate）
Name ASN007
Synonyms ASN-007; ASN 007;Erk-IN-3;
SMILES CC1=CN=C(N=C1N2C=C(N=C2)C(=O)NC(CN)C3=CC(=CC(=C3)Cl)F)NC4CCOCC4
Chemical Name
Formula C22H25ClFN7O2 M. Wt 473.93
Purity 98% Storage Store at 4-8°C
Description ASN007, a novel oral ERK inhibitor, shows robust antitumor activity in RAS mutant cancer models. with low single-digit nM IC50 values. ASN007 showed a slow dissociation rate (long target residence time) as compared to several other known ERK inhibitors. In mechanistic cell-based assays, ASN007 inhibited the phosphorylation of ERK1/2 substrates such as RSK1, FRA1, and Elk1 in various cell lines. ASN007 showed single-digit nanomolar antiproliferative activity that was selective for MAPK-pathway dependent cancer cell lines.
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