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PD184161 Chemical Structure

PD184161

Data Sheet For research use only. Not for human use.
Cat. No. :BCP46466CAS No. :212631-67-9Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 212631-67-9 Cat. No. BCP46466
Name PD184161
Synonyms PD 184161; PD-184161;
SMILES C1CC1CONC(=O)C2=CC(=C(C(=C2NC3=C(C=C(C=C3)I)Cl)F)F)Br
Chemical Name
Formula C17H13BrClF2IN2O2 M. Wt 557.56
Purity 98% Storage Store at 4-8°C
Description PD184161 is an orally-active MEK inhibitor. PD184161 inhibited MEK activity (IC50 = 10-100 nM) in a time- and concentration-dependent manner more effectively than PD098059 or U0126. PD184161 inhibited cell proliferation and induced apoptosis at concentrations of > or = 1.0 microM in a time- and concentration-dependent manner. PD184161 has antitumor effects in HCC in vitro and in vivo that appear to correlate with suppression of MEK activity. PD184161 is unable to suppress MEK activity in HCC xenografts in the long term.
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