TAS-115 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1190836-34-0 | Cat. No. | BCP34014 |
| Name | TAS-115 | ||
| Synonyms | TAS 115, TAS115; Pamufetinib; | ||
| SMILES | CNC(=O)C1=CC2=C(C=CN=C2C=C1OC)OC3=C(C=C(C=C3)NC(=S)NC(=O)CC4=CC=CC=C4)F | ||
| Chemical Name | |||
| Formula | C27H23FN4O4S | M. Wt | 518.56 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | TAS-115 is a c-MET Inhibitor. TAS-115 inhibited the kinase activity of both VEGFR2 and MET and their signal-dependent cell growth as strongly as other known VEGFR or MET inhibitors. TAS-115 is extremely selective and specific, at least in vitro. In in vivo studies, TAS-115 completely suppressed the progression of MET-inactivated tumor by blocking angiogenesis without toxicity when given every day for 6 weeks, even at a serum-saturating dose of TAS-115. TAS-115 induced marked tumor shrinkage and prolonged survival in MET-amplified human cancer-bearing mice. TAS-115 is a unique VEGFR/MET-targeted inhibitor with improved antitumor efficacy and decreased toxicity. | ||
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