CEP-11981 New
* Required Fields.
Please complete the form below and you will get the price list in 1 minute.
* Required Fields.
Please complete the form below and we will contact you shortly.
* Required Fields.
Please complete the form below and we will contact you shortly.
CAS No. | 856691-93-5 | Cat. No. | BCP46664 |
Name | CEP-11981 | ||
Synonyms | CEP11981; CEP 11981; BOL303213X; BOL-303213X; BOL 303213X; ESK981; ESK-981; ESK 981; | ||
SMILES | CC(C)CN1C2=C(C=C(C=C2)NC3=NC=CC=N3)C4=C1C5=C(C6=CN(N=C6CC5)C)C7=C4CNC7=O | ||
Chemical Name | |||
Formula | C28H27N7O | M. Wt | 477.56 |
Purity | 98% | Storage | Store at 4-8°C |
Description | CEP-11981 is a potent orally active inhibitor of multiple targets (TIE-2, VEGF-R1, 2, and 3, and FGF-R1), which having essential and nonredundant roles in tumor angiogenesis and vascular maintenance. CEP-11981 demonstrated significant preclinical cytostatic anti-tumor activity against human UC xenografts in a murine model, which was attributable to inhibition of angiogenesis. Clinical development of CEP-11981 in tolerable combination regimens and the discovery of tumor and host related biomarkers predictive for benefit are warranted. Pan-VEGFR/Tie2 tyrosine kinase inhibitor CEP-11981 selectively binds to VEGFR and Tie2 receptor tyrosine kinases, which may result the inhibition of endothelial cell migration, proliferation and survival and the inhibition of tumor cell proliferation and tumor cell death. |
Recommend Products
More >-
-
Tyrphostin AG1433
Cat. No.:BCP48941
No.:168835-90-3
Product Details -
WAY-340935
Cat. No.:BCP46895
No.:737818-56-3
Product Details -
Ningetinib
Cat. No.:BCP46143
No.:1394820-69-9
Product Details -
Tivozanib hydrochloride hydrate
Cat. No.:BCP45190
No.:682745-41-1
Product Details -
-
-
Acrizanib
Cat. No.:BCP36110
No.:1229453-99-9
Product Details -
SAR131675
Cat. No.:BCP35024
No.:1433953-83-3
Product Details -
5Z-7-Oxozeaenol
Cat. No.:BCP34467
No.:253863-19-3
Product Details -
Donafenib
Cat. No.:BCP34023
No.:1130115-44-4
Product Details -
TAS-115 mesylate
Cat. No.:BCP34015
No.:1688673-09-7
Product Details -
-
Vandetanib trifluoroacetate
Cat. No.:BCP33121
No.:338992-53-3
Product Details -
-
hVEGF-IN-1
Cat. No.:BCP32794
No.:1637443-98-1
Product Details -
-
-
-
(Z)-Guggulsterone
Cat. No.:BCP07472
No.:39025-23-5
Product Details
Tags:CEP-11981 supplier,CEP-11981 purchase,CEP-11981 manufacturer,CEP-11981 distributor,CEP-11981 cost,CEP-11981 buy,CEP-11981 for sale