SAR131675 New
Data Sheet
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| CAS No. | 1433953-83-3 | Cat. No. | BCP35024 |
| Name | SAR131675 | ||
| Synonyms | SAR 131675; SAR-131675; | ||
| SMILES | CCN1C(=C(C(=O)C2=C1N=C(C=C2)C#CC(C)(COC)O)C(=O)NC)N | ||
| Chemical Name | |||
| Formula | C18H22N4O4 | M. Wt | 358.39 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | SAR131675 is a potent and selective VEGFR-3 inhibitor. It inhibited VEGFR-3 tyrosine kinase activity and VEGFR-3 autophosphorylation in HEK cells with IC(50) values of 20 and 45 nmol/L, respectively. SAR131675 was found to be highly selective for VEGFR-3 versus 107 receptors, enzymes, ion channels, and 65 kinases. SAR131675 is the first highly specific VEGFR-3-TK inhibitor described to date, displaying significant antitumoral and antimetastatic activities in vivo through inhibition of lymphangiogenesis and TAM invasion. | ||
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