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hVEGF-IN-1 Chemical Structure

hVEGF-IN-1

Data Sheet For research use only. Not for human use.
Cat. No. :BCP32794CAS No. :1637443-98-1Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1637443-98-1 Cat. No. BCP32794
Name hVEGF-IN-1
Synonyms
SMILES CCN(CC)CCOC1=CC=C(C=C1)NC2=NC(=NC3=CC=CC=C32)C4=CC=CC=C4NC(=O)CCN5CCN(CC5)C
Chemical Name
Formula C34H43N7O2 M. Wt 581.75
Purity 98% Storage Store at 4-8°C
Description hVEGF-IN-1 represses human VEGF-A translation and shows antitumor activity.hVEGF-IN-1 shows a significant specific interaction with the G-rich region within the 5′- untranslated regions (5′-UTR) of hVEGF-A mRNA and destabilizes the Gquadruplex structure. hVEGF-IN-1 binds to the IRES-A (WT) with a Kd of 0.928 μM and binds to the hairpin DNA with a Kd of 21.2 μM. The G-rich sequence G774-G790 within the IRES-A of hVEGF-A’s 5′-UTR has been shown to be critical for the translation initiation activity of IRES-A.
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