PF-06282999

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP20203CAS No. ：1435467-37-0Purity：98%

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CAS No.	1435467-37-0	Cat. No.	BCP20203
Name	PF-06282999
Synonyms	PF06282999;PF 06282999;
SMILES
Chemical Name
Formula	C13H12ClN3O3S	M. Wt	325.77
Purity	98%	Storage	Store at 4-8°C
Description	The estimated EC50 for total 8 concentration in plasma is 3.8 μM, which corresponds well with the IC50 value obtained in the human whole blood assay of 1.9 μM. PF-06282999 is moderately bound to plasma proteins across preclinical species and humans. The blood/plasma ratios for PF-06282999 are 1.1, 1.1, 0.91, 1.2, and 0.94 in mice, rats, dogs, monkeys, and humans, respectively, suggesting that PF-06282999 is equally distributed into plasma and red blood cells. The in vivo pharmacokinetics of PF-06282999 are examined in greater detail in mice, rats, dogs, and monkeys, wherein it is demonstrated to have low CLp in mice (10.1 mL/min/kg), dogs (3.39 mL/min/kg), monkeys (10.3 mL/min/kg) and moderate CLp in rats (41.8 mL/min/kg). The terminal plasma elimination half-lives (t1/2) range from 0.75 to 3.3 h in the four species. Approximately 26-32% of the iv dose of PF-06282999 is excreted in the unchanged form in rat, dog, and monkey urine, wherein it is also shown that it is well distributed wi