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UAMC-3203 Chemical Structure

UAMC-3203

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP30684CAS No. ：2271358-64-4Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 2271358-64-4 Cat. No. BCP30684
Name UAMC-3203
Synonyms UAMC 3203;UAMC3203;
SMILES O=S(C(C=C1NCC2=CC=CC=C2)=CC=C1NC3CCCCC3)(NCCN4CCNCC4)=O
Chemical Name
Formula C25H37N5O2S M. Wt 471.7
Purity 98% Storage Store at 4-8°C
Description UAMC-3203 is an inhibitor of ferroptosis that has an IC50 value of 10 nM for inhibition of erastin-induced ferroptosis in IMR-32 neuroblastoma cells. It decreases iron-induced plasma lactate dehydrogenase (LDH) levels in a mouse model of acute iron poisoning when administered at a dose of 20 µmol/kg. It is not toxic to mice following chronic administration of a 20 µmol/kg dose for four weeks. UAMC-3203 has increased solubility and a longer half-life in mouse, rat, and human microsomes and isolated plasma than the ferroptosis inhibitor ferrostatin-1. In an in silico membrane dynamics study, UAMC-3203 was incorporated into a phospholipid bilayer.
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