CFI-400945 fumarate
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1616420-30-4 | Cat. No. | BCP25931 |
| Name | CFI-400945 fumarate | ||
| Synonyms | Ocifisertib Fumarate;CFI400945; CFI 400945; CFI-400945；CFI400945 fumarate; | ||
| SMILES | CC1CN(CC(O1)C)CC2=CC=C(C=C2)C=CC3=NNC4=C3C=CC(=C4)C5CC56C7=C(C=CC(=C7)OC)NC6=O.C(=CC(=O)O)C(=O)O | ||
| Chemical Name | |||
| Formula | C37H38N4O7 | M. Wt | 650.72 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | CFI-400945 fumarate is an orally available fumarate salt form of CFI-400945, a polo-like kinase 4 (PLK4) inhibitor with potential antineoplastic activity. Upon oral administration, polo-like kinase 4 inhibitor CFI-400945 selectively inhibits PLK4, which results in the disruption of mitosis and the induction of apoptosis. PLK4 inhibition also prevents cell division and inhibits proliferation of PLK4-overexpressing tumor cells. PLK4, a member of the polo family of serine/threonine kinases overexpressed in a variety of cancer cell types, plays a crucial role in the regulation of centriole duplication during the cell cycle. | ||
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