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CAS No. | 1082739-92-1 | Cat. No. | BCP48202 |
Name | TC-S 7005 | ||
Synonyms | TC S 7005; TCS 7005; TCS-7005; TCS7005; | ||
SMILES | CC(C1=CC=CC=C1)NC2=NC=C3C(=C2)C(=NO3)C4=CC5=C(C=C4)OCO5 | ||
Chemical Name | |||
Formula | C21H17N3O3 | M. Wt | 359.38 |
Purity | 98% | Storage | Store at 4-8°C |
Description | TC-S 7005 is a potent and selective polo-like kinase 2 (PLK2) inhibitor (IC50 = 4 nM). TC-S 7005 shows selectivity for PLK2 over PLK3 and PLK1 (IC50 values are 24 and 214 nM respectively). TC-S 7005 induces mitotic arrest and cell death in HCT 116 colorectal cells. |
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