Poloxin New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP45204CAS No. ：321688-88-4Purity：98%

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CAS No.	321688-88-4	Cat. No.	BCP45204
Name	Poloxin
Synonyms
SMILES	CC =CC=CC=C1C(=O)
Chemical Name
Formula	C18H19NO3	M. Wt	297.35
Purity	98%	Storage	Store at 4-8°C
Description	Poloxin is the first small-molecule inhibitor specifically targeting the function of the Plk1 PBD. Poloxin induces centrosome fragmentation and abnormal spindle and chromosome misalignment, which activate the spindle assembly checkpoint and prolong mitosis. Notably, centrosomal fragmentation induced by Poloxin is partially attributable to dysfunctional Kizuna, a key substrate of Plk1 at centrosomes. Moreover, Poloxin strongly inhibits proliferation of a panel of cancer cells by inducing mitotic arrest, followed by a surge of apoptosis. More important, we report, for the first time to our knowledge, that the PBD inhibitor, Poloxin , significantly suppresses tumor growth of cancer cell lines in xenograft mouse models by lowering the proliferation rate and triggering apoptosis in treated tumor tissues.