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CAS No. | GSK3685032TFA | Cat. No. | BCP45843 |
Related Products | 2170137-61-6(GSK 3685032) 2170140-50-6((R)-GSK-3685032) | ||
Name | GSK3685032 TFA | ||
Synonyms | GSK 3685032 TFA; GSK-3685032 TFA; | ||
SMILES | |||
Chemical Name | |||
Formula | C24H25F3N6O3S | M. Wt | 534.56 |
Purity | 98% | Storage | Store at 4-8°C |
Description | GSK3685032 is a first-in-class potent, non-nucleoside, reversible, DNMT1-selective inhibitor (IC50: 0.17 µM), exerting robust DNA hypomethylation and gene activation, potently inhibiting growth of cancer cell lines, displaying improved tolerability and greater DNA hypomethylation than decitabine (DAC), translating into superior antitumour activity in models of AML. |
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