NPS-1034

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP15998CAS No. ：1221713-92-3Purity：98%

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CAS No.	1221713-92-3	Cat. No.	BCP15998
Name	NPS-1034
Synonyms	NPS1034;NPS 1034;
SMILES	O=C(C1=C(C)N(C)N(C2=CC=C(F)C=C2)C1=O)NC3=CC=C(OC4=C5C(NC=C5C6=CC=CC=C6)=NC=C4)C(F)=C3
Chemical Name
Formula	C31H23F2N5O3	M. Wt	551.54
Purity	98%	Storage	Store at 4-8°C
Description	NPS-1034 is a dual Met/Axl inhibitor with IC50 of 48 nM and 10.3 nM, respectively.NPS-1034 is a novel MET inhibitor, which inhibits the activated MET receptor and its constitutively active mutants. NPS-1034, inhibits various constitutively active mutant forms of MET as well as HGF-activated wild-type MET. NPS-1034 inhibited the proliferation of cells expressing activated MET and promoted the regression of tumors formed from such cells in a mouse xenograft model through anti-angiogenic and pro-apoptotic actions. NPS-1034 also inhibited HGF-stimulated activation of MET signaling in the presence or absence of serum. Notably, NPS-1034 inhibited three MET variants that are resistant to the MET inhibitors SU11274, NVP-BVU972, and PHA665752.