S49076

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP23760CAS No. ：1265965-22-7Purity：98%

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CAS No.	1265965-22-7	Cat. No.	BCP23760
Name	S49076
Synonyms	S-49076; S 49076;
SMILES
Chemical Name
Formula	C22H22N4O4S	M. Wt	438.50
Purity	98%	Storage	Store at 4-8°C
Description	S49076 is a novel, potent inhibitor of MET, AXL/MER, and FGFR1/2/3. S49076 potently blocked cellular phosphorylation of MET, AXL, and FGFRs and inhibited downstream signaling in vitro and in vivo. In cell models, S49076 inhibited the proliferation of MET- and FGFR2-dependent gastric cancer cells, blocked MET-driven migration of lung carcinoma cells, and inhibited colony formation of hepatocarcinoma cells expressing FGFR1/2 and AXL. In tumor xenograft models, a good pharmacokinetic/pharmacodynamic relationship for MET and FGFR2 inhibition following oral administration of S49076 was established and correlated well with impact on tumor growth. MET, AXL, and the FGFRs have all been implicated in resistance to VEGF/VEGFR inhibitors such as bevacizumab. A phase I study with S-49076 is currently underway in patients with advanced solid tumors.