MK8245

参考资料仅供科学研究，不可用于个人用途。

货号：BCP02516CAS号：1030612-90-8纯度：98%

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CAS号	1030612-90-8	货号	BCP02516
中文名	MK8245
英文名	MK8245
中文别名
英文别名	MK-8245;MK 8245;
SMILES
化学名称
分子式	C17H16BrFN6O4	分子量	467.25
纯度	98%	配送	惯例下常温包邮
产品描述	MK-8245, a phenoxy piperidine isoxazole derivative, has been identified as a potent and liver-specific SCD inhibitor. It contains a tetrazole acetic acid moiety, which is the key molecule for OATPs recognition and liver-targeting. MK-8245 displays similar potencies against human, rat and mouse SCD1 with IC50 values of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1. MK-8245 exhibits a significant SCD inhibition in the rat hepatocyte assay which contains functional, active OATPs with IC50 of 68 nM, while being only weakly active in the HepG2 cell assay which is devoid of active OATPs with IC50 of ~1 μM. MK-8245 displays highly selective activity for the Δ-5 and Δ-6 desaturases (i.e., >100000 μM vs rat and human Δ5D and Δ6D as assessed in the HepG assay.