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Pim

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Pim

结构式 货号 产品名称 CAS号
PIM1-IN-1 结构式
 BCP43782 PIM1-IN-1 1417630-95-5
PIM1-IN-1 is a potent and highly selective inhibitor of PIM1/3(IC50s of 7, 5530 and 70 nM for PIM1, PIM2, and PIM3, respectively),with Antiproliferative and anti-cancer activity.
Parsaclisib hydrochloride 结构式
 BCP42656 Parsaclisib hydrochloride 1995889-48-9
Parsaclisib, also known as INCB050465, is a novel PI3Kδ inhibitor which synergizes with PIM protein kinase inhibition to cause tumor regression in a model of DLBCL.
NSC31205 结构式
 BCP32632 NSC31205 6320-51-0
NSC 31205 is a PIM2/1 inhibitor.
TCS PIM-1 1 结构式
 BCP15861 TCS PIM-1 1 491871-58-0
TCS PIM-1 1 is a potent and selective ATP-competitive Pim-1 kianse inhibitor with IC50 of 50 nM, displays good selectivity over Pim-2 and MEK1/MEK2(IC50s >20,000 nM).
SMI-4a 结构式
 BCP21212 SMI-4a 327033-36-3
SMI-4a, also called as TCS-PIM-1-4a, a thiazolidinedione compound, is a potent, selective ATP-competitive inhibitor against Pim protein kinase (IC50 = 24 nM against Pim-1 and 100 nM against Pim-2) with little or no activity against a panel of 58 other kinase.
PIM447 dihydrochloride 结构式
 BCP31128 PIM447 dihydrochloride 1820565-69-2
PIM447 is a pan-PIM kinase ihibitor with Kis of 6, 18, 9 nM for PIM1, PIM2 and PIM3, respectively.
Pim1/AKK1-IN-1 结构式
 BCP27625 Pim1/AKK1-IN-1 1093222-27-5
Pim1/AKK1-IN-1 is a potent multi-kinase inhibitor with Kd values of 35 nM/53 nM/75 nM/380 nM for Pim1/AKK1/MST2/LKB1 respectively, and also inhibits MPSK1 and TNIK.
LGB321 结构式
 BCP13641 LGB321 1210415-88-5
LGB-321 is a potent and selective ATP-competitive small molecule inhibitor of PIM kinases (Pan-PIM kinase inhibitor).
TP-3654 结构式
 BCP30070 TP-3654 1361951-15-6
TP-3654 is a second-generation Pim kinase inhibitor with Ki values of 5 and 42 nM for Pim-1 and Pim-3, respectively.
LGH447 Hydrochloride 结构式
 BCP24206 LGH447 Hydrochloride 1210416-52-6
LGH447 Hydrochloride is Potent and specific pan-PIM inhibitor, inhibiting proliferation of several AML cell lines, showing dual antitumoral and bone antiresorptive effects.
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