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Sirtuin

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Sirtuin

结构式 货号 产品名称 CAS号
Nicotinamide riboside malate 结构式
 BCP49681 烟酰胺核糖苹果酸盐 2415659-01-5
Nicotinamide riboside malate, an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3.
SIRT6 activator 12q 结构式
 BCP48517 SIRT6 activator 12q 2601734-99-8
SIRT6 activator 12q is a novel SIRT6 activator, significantly inhibiting the proliferation and migration of pancreatic ductal adenocarcinoma (PDAC) cells in vitro and markedly suppressing the tumor growth in a PDAC tumor xenograft model.
Decapeptide-12 结构式
 BCP47675 十肽-12 137665-91-9
Decapeptide-12 reversibly binds to tyrosinase, an enzyme found in a number of different pigment-producing cells.
YK-3-237 结构式
 BCP46448 YK-3-237 1215281-19-8
YK-3-237, a SIRT1 activator, targets mutant p53. YK-3-237 inhibits the proliferation of triple-negative breast cancer cells.
SIRT-IN-2 结构式
 BCP41849 SIRT-IN-2 1431411-66-3
SIRT-IN-2 is a potent inhibitor of SIRT1/2/3, with IC50s of 4, 4, 7 μM, respectively.
Selisistat S-enantiomer 结构式
 BCP41219 Selisistat S-enantiomer 848193-68-0
EX-527 S-enantiomer is the S-enantiomer of EX-527, which is a potent and selective SIRT1 inhibitor and with no inhibition on SIRT3 and SIRT3.
SBI-797812 结构式
 BCP39800 SBI-797812 2237268-08-3
SBI-797812 is a novel NAMPT activator, elevating liver NAD+, turning NAMPT into a "super catalyst" that more efficiently generates NMN.
4'-Bromo-resveratrol 结构式
 BCP37824 4'-Bromo-resveratrol 1224713-90-9
4'-Bromo-resveratrol is a potent inhibitor of the deacetylases sirtuin 1 (SIRT1) and 3 (SIRT3).
UBCS039 结构式
 BCP37615 UBCS039 358721-70-7
UBCS039 is the first synthetic Sirt6 activator.
SRT2183 结构式
 BCP37408 SRT2183 1001908-89-9
SRT 2183 is a selective Sirtuin-1 (SIRT1) activator with an EC1.5 value of 0.36 μM. SRT 2183 induces growth arrest and apoptosis, concomitant with deacetylation of STAT3 and NF-κB, and reduction of c-Myc protein levels.
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