促销产品
| 结构式 | 货号 | 产品名称 | CAS号 |
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BCP00227 | 3,4-二氨基呋扎 热 促 大货 | 17220-38-1 |
3,4-Diaminofurazan is a building block used to prepare magnesium and zinc alkynylated salicylaldehyde-diamine Schiff base complexes.
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BCP01928 | Adavosertib 新 热 促 | 955365-80-7 |
MK-1775 is a potent and selective Wee1 kinase inhibitor with an IC50 of 5.2 nM.
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BCP02173 | Galunisertib 新 促 | 700874-72-2 |
LY2157299 is a novel selective small molecule transforming growth factor beta receptor (TGF-βR) kinase inhibitor with IC50 of 86 nM and 2 nM for TβR1 and 2 nM, respectively.
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BCP01857 | 依伐卡托 新 促 大货 | 873054-44-5 |
Ivacaftor is a CFTR activator (IC50 of 43 ± 38 nM).
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BCP02523 | 罗沙司他 新 促 大货 | 808118-40-3 |
Roxadustat (FG-4592) is an oral hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitor developed for the treatment of anemia.
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BCP02532 | 艾代拉里斯 新 促 | 870281-82-6 |
Idelalisib (CAL-101; GS-1101) is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL).
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BCP17155 | Linerixibat 新 热 促 | 1345982-69-5 |
GSK2330672 is a highly potent, nonabsorbable ASBT(apical sodium-dependent bile acid transporter) inhibitor (hASBT IC50=42 ± 3 nM) .
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BCP02515 | WZ4002 新 促 | 1213269-23-8 |
WZ4002 is an EGFR T790M inhibitor(IC50<20nM).
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BCP00216 | Dactolisib 新 促 | 915019-65-7 |
BEZ235 (NVP-BEZ235) inhibits PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes. The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin inhibitor (mTOR) pathway is often constitutively activated in human tumor cells.
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BCP05748 | 维妥色替 新 促 | 1009298-59-2 |
AZD2014 is a selective inhibitor of mTOR kinase. AZD2014 decreases p4EBP1 Thr37/46, inhibits the translation initiation complex and decreases overall protein synthesis. AZD2014 also inhibits the mTORC2 biomarkers pAKTSer473 and pNDRG1 Thr346. AZD2014 inhibits proliferation and induces cell death in breast cancer cell lines, including ER+ cell lines with acquired resistance to hormone therapy.
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BCP07173 | 替扎卡托 新 促 | 1152311-62-0 |
Tezacaftor, also known asVX-661, is CFTR modulator. VX-661 is potentially useful for treatment of cystic fibrosis disease. Cystic fibrosis (CF) is a genetic disease caused by defects in the CF transmembrane regulator (CFTR) gene, which encodes an epithelial chloride channel. The most common mutation, Δ508CFTR, produces a protein that is misfolded and does not reach the cell membrane. VX-661 can correct trafficking of Δ508CFTR and partially restore chloride channel activity.
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BCP02329 | 度鲁特韦 新 促 | 1051375-16-6 |
Dolutegravir is an integrase inhibitor being developed for the treatment of human immunodeficiency virus (HIV)-1 infection by GlaxoSmithKline (GSK) on behalf of Shionogi-ViiV Healthcare LLC.
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BCP02829 | 贝达喹啉 新 促 | 843663-66-1 |
Bedaquiline, also known as TMC207 and R207910, is a diarylquinoline anti-tuberculosis drug.
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BCP20294 | Eprenetapopt 新 热 促 | 5291-32-7 |
APR-246 restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells. PRIMA-1Met also targets the selenoprotein thioredoxin reductase 1 (TrxR1), a key regulator of cellular redox balance.
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BCP01776 | 曲古菌素A 新 促 | 58880-19-6 |
Trichostatin A is a selective and potent inhibitor of histone deacetylase (Ki = 3.4 nM).
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BCP17698 | EAI045 新 促 | 1942114-09-1 |
EAI045 is an allosteric inhibitor that targets selected drug-resistant EGFR mutants.
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BCP07911 | 乙莫克舍 新 促 | 124083-20-1 |
Etomoxir is a potent inhibitor of carnitine palmitoyltransferase-I (CPT-1).
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BCP20662 | LOXO-195 新 热 促 | 2097002-61-2 |
LOXO-195 is a next-generation TRK kinase (TKI) inhibitor, with IC50s of 0.6±0.1 nM, <2.5 nM for TRKA and TRKC respectively.
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BCP20339 | BMS-986205 新 热 促 | 1923833-60-6 |
BMS-986205 is a selective indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor.
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BCP25378 | 水杨酸毒扁豆碱 促 | 57-64-7 |
Physostigmine salicylate is a reversible cholinesterase inhibitor, a parasympathomimetic alkaloid.
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