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Checkpoint

结构式 货号 产品名称 CAS号
CCT244747 结构式
 BCP23872 CCT244747 1404095-34-6
CCT244747 is a potent, orally bioavailable and highly selective CHK1 inhibitor, with an IC50 of 7.7 nM; CCT244747 also abrogates G2 checkpoint with an IC50 of 29 nM.
SB218078 结构式
 BCP25033 SB218078 135897-06-2
SB-218078 is a potent and selective indolocarbazole chk1 inhibitor.
Chk2 Inhibitor 结构式
 BCP46034 Chk2 Inhibitor 724708-21-8
Chk2 inhibitor is an inhibitor of checkpoint kinase 2 (Chk2).
Prexasertib mesylate 结构式
 BCP40573 Prexasertib mesylate 1234015-55-4
Prexasertib, also known as LY2606368, is a potent and selective Chk1/Chk2 inhibitor.
Prexasertib dimesylate 结构式
 BCP35489 Prexasertib dimesylate 1234015-58-7
Prexasertib dimesylate (LY2606368 dimesylate) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of <1 nM.
V158411 结构式
 BCP25319 V158411 1174664-88-0
V158411 is a novel selective Chk1 inhibitor.
LY2880070 结构式
 BCP32047 LY2880070 1375637-35-6
LY2880070 is a new checkpoint kinase 1 (CHK1) inhibitor for cancer therapy. CHK1 is a serine/threonine kinase.
CCT241533 结构式
 BCP21396 CCT241533 1262849-73-9
CCT241533 is a potent and selective Inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors.
GDC0575 hydrochloride 结构式
 BCP30767 GDC0575 hydrochloride 1196504-54-7
GDC-0575 (ARRY-575, RG7741) is a highly-selective oral small-molecule Chk1 inhibitor with an IC50 of 1.2 nM.
GDC-0575 dihydrochloride 结构式
 BCP29768 GDC-0575 dihydrochloride 1657014-42-0
GDC-0575 dihydrochloride is an orally bioavailable CHK1 inhibitor, with an IC50 of 1.2 nM, and has antitumor activity.
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