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IDH

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IDH

结构式 货号 产品名称 CAS号
GSK864 结构式
 BCP38009 GSK864 1816331-66-4
GSK864 is a cell penetrant, selective allosteric inhibitor of isocitrate dehydrogenase 1 (IDH1) mutant with IC50 values of 8.8, 15.2 and 16.6 nM for IDH1 mutants R132C, R132H, and R132G, respectively.
DS-1001B 结构式
 BCP32722 DS-1001B 1898207-64-1
DS-1001B is a mutant IDH-1 (Isocitrate Dehydrogenase-1) inhibitor extracted from patent WO2016052697A1, Example 168, and has antitumor activity.
IDH889 结构式
 BCP32439 IDH889 1429179-07-6
IDH889 is an orally available, brain penetrant, allosteric and mutant specific inhibitor of isocitrate dehydrogenase 1 (IDH1). IDH889 has potent selectivity for IDH1 R132* mutations, with IC50s of 0.02 μM, 0.072 μM and 1.38 μM for IDH1R132H, IDH1R132C and IDH1wt, respectively. IDH889 shows potent cellular inhibition of R-2-hydroxyglutarate (2-HG) production with an IC50 of 0.014 μM.
Olutasidenib 结构式
 BCP30919 Olutasidenib 1887014-12-1
Olutasidenib is a potent, selective inhibitor of mutant Isocitrate dehydrogenase (IDH)1 for the treatment of acute myeloid leukemia.
IDH-305 结构式
 BCP30411 IDH-305 1628805-46-8
IDH-305 is an inhibitor of isocitrate dehydrogenase (IDH).
GSK321 结构式
 BCP20143 GSK321 1816331-63-1
GSK321 is a potent and selective IDH1 mutant inhibitor.
BAY-1436032 结构式
 BCP18989 BAY-1436032 1803274-65-8
BAY-1436032 is a novel pan-mutant isocitrate dehydrogenase 1 (IDH1) inhibitor.
Mutant IDH1-IN-1 结构式
 BCP13615 Mutant IDH1-IN-1 1355326-21-4
Mutant IDH1-IN-1 is a potent mutant IDH1 R132H inhibitor with IC50 < 0.1 uM(A level in Patent); more bioactivity information in Patent WO2012009678A1.
Mutant IDH1 inhibitor 结构式
 BCP16459 Mutant IDH1 inhibitor 1429180-08-4
Mutant IDH1 Inhibitor is a potent mutant IDH1 R132H inhibitor with IC50 of < 72 nM.
Mutant IDH1-IN-2 结构式
 BCP16464 Mutant IDH1-IN-2 1429176-69-1
Mutant IDH1-IN-2 is a inhibitor of mutant Isocitrate dehydrogenase (IDH) proteins, with IC50 of in LS-MS biochemical assay, IC50 of 16.6 nM in Fluorescence biochemical assay.
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