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| CAS号 | 1056901-62-2 | 货号 | BCP08961 |
| 中文名 | AT13148 | ||
| 英文名 | AT13148 | ||
| 中文别名 | |||
| 英文别名 | AT 13148; AT-13148; | ||
| SMILES | |||
| 化学名称 | |||
| 分子式 | C17H16ClN3O | 分子量 | 313.78 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | AT13148 is a novel oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity, which shows a distinct mechanism of action from other AKT inhibitors. AT13148 is currently being developed by Astex Pharmaceuticals. AT131148 was identified utilizing high-throughput X-ray crystallography and fragment-based lead discovery techniques. AT13148 caused substantial blockade of AKT, p70S6K, PKA, ROCK and SGK substrate phosphorylation and induction of apoptosis in both a concentration and time-dependent manner in cancer cells with clinically relevant genetic defects both in vitro and in vivo. | ||
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