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| CAS号 | 1061353-68-1 | 货号 | BCP10711 |
| 中文名 | PND-1186 | ||
| 英文名 | PND-1186 | ||
| 中文别名 | |||
| 英文别名 | PND1186;PND 1186; SR 2516; SR2516; SR2516; VS4718; VS4718; VS 4718; | ||
| SMILES | |||
| 化学名称 | |||
| 分子式 | C25H26F3N5O3 | 分子量 | 501.5 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | PND-1186, also known as SR-2156 and VS-4718, is a potent FAK inhibitor with a 50% inhibitory concentration (IC50) of 1.5 nM in vitro. PND-1186 has an IC50 of ~100 nM in breast carcinoma cells. Notably, 1.0 µM PND-1186 (>5-fold above IC50) had limited effects on cell proliferation. However, under non-adherent conditions as spheroids and as colonies in soft agar, 0.1 µM PND-1186 blocked FAK and p130Cas tyrosine phosphorylation, promoted caspase-3 activation, and triggered cell apoptosis. PND-1186 inhibited 4T1 breast carcinoma subcutaneous tumor growth correlated with elevated tumor cell apoptosis and caspase 3 activation. | ||
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