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| CAS号 | 124750-92-1 | 货号 | BCP08038 |
| 中文名 | 氯沙坦 | ||
| 英文名 | Losartan Carboxylic Acid | ||
| 中文别名 | |||
| 英文别名 | EXP-3174; EXP 3174; EXP3174; E-3174; E 3174; E3174; | ||
| SMILES | |||
| 化学名称 | |||
| 分子式 | C22H21ClN6O2 | 分子量 | 436.89 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | EXP-3174, also known as Losartan Carboxylic Acid, is a physiologically active metabolite of losartan, produced by cytochrome P450 isoforms in the liver. Like the parent compound, EXP-3174 is a potent AT1 antagonist (Kis = 0.57 and 0.67 nM for rat and human forms, respectively), producing a depressor response and vasodilatation. When administered intravenously, losartan carboxylic acid is more potent and has a longer duration of action than losartan. However, the metabolite has very low oral bioavailability. | ||
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