GSK621 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP31970CAS号：1346607-05-3纯度：98%

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CAS号	1346607-05-3	货号	BCP31970
中文名	GSK621
英文名	GSK621
中文别名
英文别名	GSK-621; GSK 621;
SMILES	COC1=CC=CC(=C1)N2C(=O)C3=C(C=C(N3C4=CC=C(C=C4)C5=C(C(=CC=C5)OC)O)Cl)NC2=O
化学名称
分子式	C26H20ClN3O5	分子量	489.91
纯度	98%	配送	惯例下常温包邮
产品描述	GSK621 is a potent and selective AMPK agonist. GSK621 selectively kills acute myeloid leukemia (AML) cells but spares normal hematopoietic progenitors. This differential sensitivity results from a unique synthetic lethal interaction involving concurrent activation of AMPK and mTORC1. Strikingly, the lethality of GSK621 in primary AML cells and AML cell lines is abrogated by chemical or genetic ablation of mTORC1 signaling. Cytotoxicity in AML cells from GSK621 involves the eIF2α/ATF4 signaling pathway that specifically results from mTORC1 activation. AMPK activation may represent a therapeutic opportunity in mTORC1-overactivated cancers.