沙库比曲钙盐新

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货号：BCP11897CAS号：1369773-39-6纯度：98%

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CAS号	1369773-39-6	货号	BCP11897
中文名	沙库比曲钙盐
英文名	Sacubitril hemicalcium salt
中文别名
英文别名	LCZ696 hemicalcium salt; LCZ 696 hemicalcium salt; LCZ696 hemicalcium salt;AHU-377 hemicalcium salt;AHU377 hemicalcium salt;AHU 377 hemicalcium salt;
SMILES	CCOC(=O)C(C)CC(CC1=CC=C(C=C1)C2=CC=CC=C2)NC(=O)CCC(=O)[O-].CCOC(=O)C(C)CC(CC1=CC=C(C=C1)C2=CC=CC=C2)NC(=O)CCC(=O)[O-].[Ca+2]
化学名称
分子式	2(C24H28NO5).Ca	分子量	861.04
纯度	98%	配送	惯例下常温包邮
产品描述	LCZ696 is a novel single molecule comprising molecular moieties of valsartan and NEP inhibitor prodrug AHU377 (1:1 ratio). Oral administration of LCZ696 caused dose-dependent increases in atrial natriuretic peptide immunoreactivity (due to NEP inhibition) in Sprague-Dawley rats and provided sustained, dose-dependent blood pressure reductions in hypertensive double-transgenic rats. In healthy participants, a randomized, double-blind, placebo-controlled study (n = 80) of single-dose (200-1200 mg) and multiple-dose (50-900 mg once daily for 14 days) oral administration of LCZ696 showed that peak plasma concentrations were reached rapidly for valsartan (1.6-4.9 hours), AHU377 (0.5-1.1 hours), and its active moiety, LBQ657 (1.8-3.5 hours). LCZ696 is superior to valsartan alone in reducing blood pressure. Preliminary results from a Phase II trial showed that LCZ696 reduced NT-proBNP to a greater extent than valsartan alone, and in addition LCZ696 had beneficial effects on symptoms.

沙库比曲钙盐 新