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| CAS号 | 1422144-42-0 | 货号 | BCP24703 |
| 中文名 | 奈他地尔 二甲磺酸盐 | ||
| 英文名 | Netarsudil mesylate | ||
| 中文别名 | |||
| 英文别名 | AR-13324 mesylate;AR13324 mesylate;AR 13324 mesylate; | ||
| SMILES | |||
| 化学名称 | |||
| 分子式 | C30H35N3O9S2 | 分子量 | 645.74 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | Netarsudil, also known as AR-11324, is a Rho-associated protein kinase inhibitor. Netarsudil is potential useful for treating glaucoma and/or reducing intraocular pressure. Netarsudil Increases Outflow Facility in Human Eyes Through Multiple Mechanisms. Netarsudil inhibited kinases ROCK1 and ROCK2 with a Ki of 1 nM each, disrupted actin stress fibers and focal adhesions in TM cells with IC50s of 79 and 16 nM, respectively, and blocked the profibrotic effects of TGF-β2 in HTM cells. Netarsudil produced large reductions in IOP in rabbits and monkeys that were sustained for at least 24 h after once daily dosing, with transient, mild hyperemia observed as the only adverse effect. | ||
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