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CAS号 | 1513857-77-6 | 货号 | BCP31812 |
中文名 | 培米加替尼 | ||
英文名 | Pemigatinib | ||
中文别名 | |||
英文别名 | INCB054828; INCB-054828; INCB 054828; INCB54828; INCB 54828; INCB-54828; | ||
SMILES | CCN1C2=C3C=C(NC3=NC=C2CN(C1=O)C4=C(C(=CC(=C4F)OC)OC)F)CN5CCOCC5 | ||
化学名称 | |||
分子式 | C24H27F2N5O4 | 分子量 | 487.5 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | Pemigatinib is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) types 1, 2, and 3 (FGFR1/2/3), with potential antineoplastic activity. Pemigatinib binds to and inhibits FGFR1/2/3, which may result in the inhibition of FGFR1/2/3-related signal transduction pathways. This inhibits proliferation in FGFR1/2/3-overexpressing tumor cells. FGFR, a family of receptor tyrosine kinases upregulated in many tumor cell types, plays a key role in cellular proliferation, migration, and survival. |
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