GSK484盐酸盐新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP25415CAS号：1652591-81-5纯度：98%

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CAS号	1652591-81-5	货号	BCP25415
中文名	GSK484盐酸盐
英文名	GSK484 hydrochloride
中文别名
英文别名	GSK-484 HCl; GSK484 HCl;GSK 484 HCl;
SMILES	CN1C2=C(C=C(C=C2OC)C(=O)N3CCC(C(C3)N)O)N=C1C4=CC5=CC=CC=C5N4CC6CC6.Cl
化学名称
分子式	C27H31N5O3	分子量	473.58
纯度	98%	配送	惯例下常温包邮
产品描述	GSK484 is a potent PAD-4 inhibitor (Protein-arginine deiminase type-4). GSK484 potently binds to the low-calcium form of PAD4 in a reversible manner (IC50 of 50 nM) and appears to be competitive with substrate. GSK484’s selectivity for PAD4 over PAD1-3 was shown in cells and also confirmed with recombinant enzymes. This probe is an inhibitor of cellular citrullination in primary neutrophils, and further phenotypic profiling has confirmed its ability to inhibit NET formation in both mouse and human neutrophils. GSK484 exhibits favourable pharmacokinetic profiles, with low-moderate clearance, and good volume of distribution and half-life in mouse and rat, and has suitable a PK profile for use as a potential in vivo tool.

GSK484盐酸盐 新