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CAS号 | 1672666-67-9 | 货号 | BCP30945 |
中文名 | PT-2385 R-Enantiomer | ||
英文名 | PT-2385 R-Enantiomer | ||
中文别名 | |||
英文别名 | PT2385 R-Enantiomer; PT 2385 R-Enantiomer; | ||
SMILES | CS(=O)(=O)C1=C2C(C(CC2=C(C=C1)OC3=CC(=CC(=C3)C#N)F)(F)F)O | ||
化学名称 | |||
分子式 | C17H12F3NO4S | 分子量 | 383.34 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | PT2385 is an orally active, small molecule inhibitor of hypoxia inducible factor (HIF)-2alpha, with potential antineoplastic activity. Upon oral administration, HIF-2alpha inhibitor PT2385 allosterically binds to HIF-2alpha, thereby preventing HIF-2alpha heterodimerization and its subsequent binding to DNA. This results in decreased transcription and expression of HIF-2alpha downstream target genes, many of which regulate tumor cell growth and survival. |
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