达比加群酯

参考资料仅供科学研究，不可用于个人用途。

货号：BCP02864CAS号：211915-06-9纯度：98%

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CAS号	211915-06-9	货号	BCP02864
中文名	达比加群酯
英文名	Dabigatran etexilate
中文别名
英文别名	Prazaxa;BIBR 1048;BIBR-1048;BIBR1048;
SMILES
化学名称
分子式	C34H41N7O5	分子量	627.73
纯度	98%	配送	惯例下常温包邮
产品描述	Dabigatran selectively and reversibly inhibits human thrombin (Ki: 4.5 nM) as well as thrombin-induced platelet aggregation (IC50: 10 nM), while showing no inhibitory effect on other platelet-stimulating agents. Dabigatran selectively and reversibly inhibits human thrombin (Ki: 4.5 nM) as well as thrombin-induced platelet aggregation (IC50: 10 nM), while showing no inhibitory effect on other platelet-stimulating agents. Dabigatran inhibits thrombin generation in platelet-poor plasma (PPP) with IC50 of 0.56 μM, measured as the endogenous thrombin potential (ETP). Dabigatran demonstrates concentrationdependent anticoagulant effects in various species in vitro, doubling the activated partial thromboplastin time (aPTT), prothrombin time (PT) and ecarin clotting time (ECT) in human PPP at concentrations of 0.23, 0.83 and 0.18 μM, respectively.