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| CAS号 | 2241337-84-6 | 货号 | BCP42710 |
| 中文名 | AT-527 | ||
| 英文名 | AT-527 | ||
| 中文别名 | |||
| 英文别名 | AT527;AT 527; | ||
| SMILES | |||
| 化学名称 | |||
| 分子式 | C24H35FN7O11PS | 分子量 | 679.61 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | AT-527, a hemisulfate salt of AT-511, a guanosine nucleotide prodrug, is a potent and orally active HCV viral replication inhibitor. AT-527 is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC90=0.47 μM). AT-527 has pangenotypic antiviral activity[1][2][3].AT-511 has pan-genotypic antiviral activities that inhibits HCV genotype 1a (HCV GT1a), HCV GT1b, HCV GT2a, HCV GT3a, HCV GT4a, and HCV GT5a replication with EC50 values of 12.8 nM, 12.5 nM, 9.2 nM, 10.3 nM, 14.7 nM, and 28.5 nM, respectively[1]. In normal human airway epithelial cells, the concentration of AT-511 required to inhibit replication of SARS-CoV-2 by EC90 is 0.47 μM, very similar to its EC90 against HCoV-229E, HCoV-OC43 and SARS-CoV in Huh-7 cells. | ||
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