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| CAS号 | 2244987-03-7 | 货号 | BCP46385 |
| 中文名 | CDK12-IN-2 | ||
| 英文名 | CDK12-IN-2 | ||
| 中文别名 | |||
| 英文别名 | CDK12 inhibitor 2; | ||
| SMILES | CN1C=C(C=CC1=O)C2=CC=C(C=C2)N(C3CCC(CC3)NC4=NC=C(C=C4)C#N)C(=O)NCC5=CC=CC=C5 | ||
| 化学名称 | |||
| 分子式 | C32H32N6O2 | 分子量 | 532.64 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | CDK12-IN-2 is a potent, selective and nanomolar CDK12 inhibitor (IC50=52 nM) with good physicochemical properties. CDK12-IN-2 is also a strong CDK13 inhibitor due to CDK13 is the closest homologue of CDK12. CDK12-IN-2 shows excellent kinase selectivity for CDK12 over CDK2, 9, 8, and 7. CDK12-IN-2 inhibits the phosphorylation of Ser2 in the C-terminal domain of RNA polymerase II. CDK12-IN-2 can be used an excellent chemical probe for functional studies of CDK12. | ||
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