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| CAS号 | 2342583-66-6 | 货号 | BCP30832 |
| 中文名 | NCC007 | ||
| 英文名 | NCC007 | ||
| 中文别名 | |||
| 英文别名 | NCC-007; NCC 007; | ||
| SMILES | FC(C1=CC(CNC2=C3N=CN(C(C4CC4)C)C3=NC(NCCN(C)C)=N2)=CC=C1)(F)F | ||
| 化学名称 | |||
| 分子式 | C22H28F3N7 | 分子量 | 447.51 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | NCC007 is a novel CKIα and CKIδ dual inhibitor. NCC007 that showed stronger period effects (0.32 μM for 5 h period lengthening) in a cellbased circadian assay. The following in vitro kinase assay showed that NCC007 inhibited CKIα and CKIδ with an IC50 of 1.8 and 3.6 μM. We further demonstrated that NCC007 lengthened the period of mouse behavioral rhythms in vivo. Thus, NCC007 is a valuable tool compound to control circadian rhythms through CKI inhibition. | ||
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