T0901317 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP03658CAS号：293754-55-9纯度：98%

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CAS号	293754-55-9	货号	BCP03658
中文名	T0901317
英文名	T0901317
中文别名
英文别名	T-0901317;T 0901317; T-1317; T1317; T 1317; TO-91317; TO 901317; TO 901317; TO-091317; TO 091317; TO091317;
SMILES	OC(C(F)(F)F)(C(F)(F)F)C1=CC=C(N(CC(F)(F)F)S(C2=CC=CC=C2)(=O)=O)C=C1
化学名称
分子式	C17H12F9NO3S	分子量	481.33
纯度	98%	配送	惯例下常温包邮
产品描述	T0901317 acts through LXR and in concert with its RXR heterodimerization partner induces the expression of the ABCA1 reverse cholesterol transporter. T0901317 upregulates expression of the ABCA1 gene associated with cholesterol efflux regulation and HDL metabolism.T0901317 displays an EC50 of ~ 5 μM for activation of bile acid farnesoid X receptors (FXRs), 10-fold more potent than natural FXR ligand chenodeoxycholic acid. T0901317, is also a high-affinity ligand for the xenobiotic receptor pregnane X receptor (PXR). T0901317 binds and activates PXR with the same nanomolar potency with which it stimulates LXR activity.