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CAS号 | 364782-34-3 | 货号 | BCP02533 |
中文名 | 盐酸甲状旁腺激素 | ||
英文名 | Cinacalcet hydrochloride | ||
中文别名 | 盐酸西那卡赛;西那卡赛盐酸盐; | ||
英文别名 | Cinacalcet HCl;Mimpara;Sensipar;AMG-073;AMG 073;AMG073; | ||
SMILES | CC(C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F.Cl | ||
化学名称 | |||
分子式 | C22H22F3N.HCl | 分子量 | 393.88 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | Cinacalcet Hydrochloride is the orally bioavailable hydrochloride salt of the calcimimetic cinacalcet. Cinacalcet increases the sensitivity of calcium-sensing receptors on chief cells in the parathyroid gland to extracellular calcium, thereby reducing parathyroid hormone (PTH) secretion. A reduction in PTH levels inhibits osteoclast activity, which may result in a decrease in cortical bone turnover and bone fibrosis, and normalization of serum calcium and phosphorus levels. In addition, by reducing PTH levels, cinacalcet may reduce PSA levels; PTH appears to raise PSA levels and may increase prostate cancer cell growth. |
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