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| CAS号 | 425671-29-0 | 货号 | BCP34904 |
| 中文名 | LY518674 | ||
| 英文名 | LY518674 | ||
| 中文别名 | |||
| 英文别名 | LY-518674; LY 518674;LY-674;LY 674;LY674; | ||
| SMILES | CC1=CC=C(C=C1)CN2C(=O)NC(=N2)CCCC3=CC=C(C=C3)OC(C)(C)C(=O)O | ||
| 化学名称 | |||
| 分子式 | C23H27N3O4 | 分子量 | 409.49 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | LY518674 is a Potent and selective PPAR-alpha agonist. LY518674 upregulates both ApoA-I production and catabolism in human subjects with the metabolic syndrome. LY518674 produced a dose-dependent increase in serum HDL-c, resulting in 208 +/- 15% elevation at optimum dose. In cultured hepatocytes, LY518674 produced 50% higher apoA-1 secretion, which was associated with increase in radiolabeled methionine incorporation in apoA-1. LY518674 is a potent and selective PPARalpha agonist that produced a much greater increase in serum HDL-c than the known fibrate drugs. | ||
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